About NAD+

Mechanism of Action: Nicotinamide adenine dinucleotide (NAD⁺) is a coenzyme essential for redox reactions, energy metabolism, and cellular repair. Injectable NAD⁺ is thought to boost intracellular NAD⁺ levels, supporting mitochondrial function and sirtuin activity.

Indications & Off-Label Uses: No FDA-approved indications for injectable NAD⁺. Off-label use includes “anti-aging,” cognitive enhancement, fatigue reduction, addiction recovery, and improved athletic performance, though clinical evidence is limited.

FDA Status: Not FDA-approved for any indication; available through compounding pharmacies.

Clinical Evidence: Small studies and case reports suggest potential benefits in addiction recovery, energy metabolism, and mitochondrial support. Robust, large-scale randomized trials are lacking.

Safety & Monitoring: Generally well tolerated; possible adverse effects include nausea, flushing, dizziness, headache, and injection-site reactions. Long-term safety data are limited.